Collagen Peptides: From Bioactivity to Biolift

Abstract

Collagen peptides are bioactive fragments derived from hydrolyzed collagen that stimulate dermal fibroblasts and enhance extracellular matrix formation. Their targeted action helps restore skin structure, elasticity, and hydration.

Introduction

With aging, collagen production declines while enzymatic degradation accelerates. Supplementation with low molecular weight collagen peptides has shown to upregulate synthesis of types I and III collagen, reversing visible signs of skin aging.

Mechanism of Action

Specific peptides bind to fibroblast receptors, activating TGF-β and MAPK signaling pathways. This promotes new collagen and hyaluronic acid synthesis, improving dermal density and reducing wrinkles.

Scientific Evidence

• VERISOL® and Naticol® peptides have demonstrated clinical improvements in skin elasticity, hydration, and wrinkle reduction.

• Bioavailability studies confirm absorption and integration into the skin matrix.

Conclusion

Collagen peptides function as signaling molecules to regenerate skin from within. Their use in nutricosmetics is backed by mechanistic and clinical validation.

References:

1. Choi, S. Y., Ko, E. J., Lee, Y. H., Kim, B. G., Shin, H. J., Seo, D. B., & Lee, S. J. (2014). Effects of collagen tripeptide supplement on skin properties: a prospective, randomized, controlled study. Journal of Cosmetic and Laser Therapy, 16(3), 132–137. https://doi.org/10.3109/14764172.2013.854121

2. Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J., & Oesser, S. (2014). Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study. Skin Pharmacology and Physiology, 27(1), 47–55. https://doi.org/10.1159/000351376

3. Metagenics Institute. (2023). Technical summary: VERISOL® Collagen and Sodium Hyaluronate for Skin Health. https://www.metagenicsinstitute.com.au/tech-data/verisol-collagen-sodium-hyaluronate-skin-health

4. PMCID: PMC9843708. (2023). Fish collagen peptides enhance skin health and hydration in clinical trials. National Library of Medicine. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9843708/

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Figure 1. Overview of the actions of VERISOL® Collagen and Sodium Hyaluronate for Skin Health.

Fig 2. Effects of NaticolⓇ on skin moisture-related factors, hyaluronic acid (A), sphingomyelin (B), TNF-α (C), IL-1β (D), IL-6 (E), HAS2 (F), LCB1(SPT) (G), DEGS1 (H), and elastin (I), in HaCaT cells exposed to UVB. Cells were treated with UVB (50 mJ/cm2), except NC, and incubated for 24 h with 100 µg/mL of L-ascorbic acid (PC) and various concentrations (100, 200, and 400 µg/mL) of NaticolⓇ collagen. Values are presented as mean±SD. Different letters (a-e) represent significant differences at P<0.05, as determined by Duncan’s multiple range test. Primers used for gene expression analysis are listed in Table 2. TNF, tumor necrosis factor; NC, normal control; C, control; PC, positive control; UVB, ultraviolet B.

Fig 3. Effects of NaticolⓇ on morphological and histopathological changes (hematoxylin and eosin staining, 20˟) (A), skin hydration (B), antioxidant activities of SOD (C), catalase (D), and GPx (E) in the dorsal skin of SKH-I hairless mice exposed to UVB. NC, AIN93G; C, UVB irradiation+AIN93G; PC1, UVB irradiation+AIN93G with L ascorbic acid (100 mg/kg); PC2, UVB irradiation+AIN93G with arbutin (100 mg/kg); NaticolⓇ150, UVB irradiation+AIN93G with NaticolⓇ collagen (150 mg/kg); NaticolⓇ300, UVB irradiation+AIN93G with NaticolⓇ collagen (300 mg/kg). Values are presented as mean±SD. Different letters (a-e) represent significant differences at P<0.05, as determined by Duncan’s multiple range test. NC, normal control; C, control; PC, positive control; UVB, ultraviolet B.