Sinetrol®: Scientific Foundation of a Natural Fat Burner

Abstract

Sinetrol® is a patented blend of Mediterranean citrus extracts designed to support fat metabolism. Its efficacy is supported by multiple clinical studies demonstrating its role in reducing abdominal fat, improving metabolic markers, and enhancing lipolysis.

Introduction

Sinetrol® is derived from citrus fruits rich in polyphenols, particularly flavonoids like naringin and hesperidin. These compounds have been extensively studied for their metabolic health benefits.

Sinetrol® is a natural combination of citrus polyphenols proven to provide the benefits of adipose beiging to increase energy expenditure, and thus amplifying lipolysis and reducing excess fat mass. Sinetrol® improves long-term body composition. Supported with published clinical trials on Asian and Caucasian subjects.

Mechanism of Action

Sinetrol® promotes lipolysis by inhibiting the phosphodiesterase enzyme (PDE), which increases cyclic AMP (cAMP) levels, thereby enhancing fat breakdown. It also exhibits antioxidant and anti-inflammatory properties.

Sinetrol® plays a role in the inhibition of PDE-3, leading to higher level of cAMP which increases the breakdown of triglycerides and release of FFAs.

Sinetrol® - Key features

• Proven mechanism of action: lipolysis enhancer providing adipose beiging benefits

• Increase in resting energy expenditure

• Rebalanced body composition: significant reduction of body fat mass without lean mass loss

• Significant results on body weight, waist and hip lines

• Long-lasting benefits: subjects continue to benefit from adipose beiging

Clinical Evidence

In a randomized double-blind study (Dallas et al., 2014), participants consuming Sinetrol® experienced a significant reduction in abdominal fat and waist circumference over 12 weeks compared to placebo.

• The increase in metabolic rate leads to a significant reduction of subjects' total body weight compared to the placebo group.

• 100% of the weight loss is from fat mass.

• Body composition is rebalanced: lean to fat-mass ratio significantly improves with Sinetrol®.

• 65% of the total fat loss is from the trunk area: the Index of Central Obesity decreases significantly.

• Waist and hip lines significantly decrease.

Sinetrol® supports long-lasting metabolic benefits

A follow-up one month after the end of the supplementation confirms that Sinetrol® provides lasting benefits for body composition.

• Subjects continue to lose body weight.

• Subjects continue to reduce body fat mass.

Relevance to ENVILT

Sinetrol® is a cornerstone ingredient in our Slim+ TrimMax Complex™, selected for its scientifically validated effect on fat metabolism and body composition improvement. Its natural origin aligns with our commitment to clean, effective formulations.

References

1. CLINICAL TRIALS

2. Dallas et al. 2008; Phytomedicine

3. Dallas et al. 2013; Phytother. Res.

4. Cases et al. 2015; Int. J. Food Sci. Nutr.

5. Park et al. 2020; J. Med Food

6. MECHANISTIC STUDIES

7. Yoo et al. 2016; J. Korean Soc. Food Sci. Nutr

8. Lee et al. 2017; J. Korean Soc. Food Sci. Nutr.

9. BIOAVAILABILITY & NUTRIKINETIC

10. Muralidharan J. et al. 2023; Food Funct.

11. Source: https://www.fytexia.com/en/health-areas/metabolism-body-composition/fat-loss-for-the-long-term-sinetrol/

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Fig 1. Sinetrol® plays a role in the inhibition of PDE-3, leading to higher level of cAMP which increases the breakdown of triglycerides and release of FFAs.

Fig 2. The increased cAMP level induced by Sinetrol® promotes higher expression of uncoupling proteins in beige adipose tissue. The FFAs released are dissipated as heat rather than restored as adipocytes.

The basal metabolic rate is increased indicating adipose beiging benefits.